Author's response to reviews Title: Stem cell abundant protein Nanog, Nucleostemin and Musashi1 highly expressed in malignant cervical epithelial cells Authors:

بررسی تأثیر مهار بیان ژن نوکلئوستمین بوسیله siRNA بر مهار رشد و القاء تمایز در رده سلولی NB4 لوسمی پرومیلوسیتیک حاد انسانی

 Background & Aims: Acute promyelocytic leukemia (APL) is a malignant hematopoietic disorder caused by indefinite proliferation and lack of differentiation of leukemia stem cells. Elucidation of signaling pathways involved in leukemic stem cells are current strategies in treatment of leukemias. In this content, nucleostemin (NS) plays a critical role in proliferation and self renewal of stem an...

LncRNA Miat Promotes Proliferation of Cervical Cancer Cells and Acts as an Anti-apoptotic Factor

There are a sub-population of cells in tumor tissues known as cancer stem cells (CSCs) which have similar features with stem cells, including self-renewal and differentiation capacity. Recently, it was established that not only stem cells factors such as Oct4, but also ES-associated lncRNAs are contributing to various regulatory aspects of CSCs. Myocardial infarction associated transcript (MIAT...

Author's response to reviews Title: TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells Authors:

Author's response to reviews Title: Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy Authors:

Functional Inhibition of Nucleostemin Gene-Acoordinator of Self-Renewal Ability-In Bone Marrow Derived Mesenchymal Stem Cells by Rnai Strategy

Purpose: The aim is to downregulate the expression level of NS as an important factor in sustaining stem cells and certain types of cancer cells self-renewal ability in bone marrow derived mesenchymal stem cells by RNAi strategy and investigate the effects of absence of NS in these cells. Materials and Methods: Double strand NS-specific and control siRNA oligos were designed and transfected in...